Format
Scientific article
Publication Date
Published by / Citation
Palpacuer C., Duprez R., Huneau A. et al. Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate. Addiction: 2017, in press.
Keywords
alcohol
nalmefene
naltrexone
acamprosate
baclofen
topiramate
anticonvulsant
pharmacotherapy
treatment
meta-analysis
side effects
mortality

No Clear Role for Medications in Less Dependent Drinkers

In 2013 nalmefene was authorised for moderating drinking among patients not in need of detoxification, extending pharmacotherapy to less dependent drinkers. Though uniquely authorised for this purpose, this review found other (and probably cheaper) drugs have been just as or possibly more effective, but for none was there high quality evidence, and for some substantial safety concerns.

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