This interesting text is the product of collaboration between the Institute of care and prevention of addictions (IAPA) and the National Institute of Psychiatry Ramón de la Fuente Muñiz (INFRDM), institutions that share the commitment to generate knowledge about problems associated with the inequity, the conditions of life of the indigenous population and the consumption of psychoactive substances. This study aims to know the levels of consumption of alcohol, tobacco, and other drugs of the schoolchildren and high school as well as to identify the factors of consumption of alcohol, tobacco and other substances in both men and women) adolescents and adults) of five native indigenous groups.