Neuroscience of Psychoactive Substance Use and Dependence

This report describes our current understanding of the neuroscience of psychoactive substance use and dependence. It draws on the explosive growth in knowledge in this area in recent decades, which has transformed our understanding of the biochemical action of psychoactive substances, and contributed new insights into why many people use them, and why some use them to the extent of causing harm or of becoming dependent on them.

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