animal model

Abstract Animal models of alcohol (ethanol) self-administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and...

More than 85% of people who give up an addictive drug begin using it again within a year. Relapse can occur following exposure to cues that are found in the environment which trigger the memory of their drug-taking experience. These cues...

Negative social interactions and isolation have been linked with heightened risk of drug self-administration and relapse, whereas positive social interactions can act as a protective factor against substance abuse. Recent research...

Abstract Novel molecular targets are needed to develop new medications for the treatment of cocaine addiction. Here we investigated a role for glucagon-like peptide-1 (GLP-1) receptors in the reinstatement of cocaine-seeking behavior, an...