morphine

The relationship between early childhood trauma and the rewarding effects of morphine

Scientific article

Research from the University of Exeter has highlighted how childhood trauma can make individuals more sensitive to the pleasurable and motivational effects of opioids and less sensitive to the negative consequence of the drugs. The research...

A randomised, double-blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine

Scientific article

21 June 2021

Experiences of childhood trauma (abuse and neglect) are disproportionately higher in those with opioid use disorder (OUD). Childhood trauma may affect the reinforcing and rewarding properties of opioid drugs and responses to pain, potentially via developmental changes to the endogenous opioid system.

Alternatively Spliced Mu Opioid Receptor C Termini Impact the Diverse Actions of Morphine

Scientific article

20 March 2017

Abstract Extensive 3′ alternative splicing of the mu opioid receptor gene OPRM1 creates multiple C-terminal splice variants. However, their behavioral relevance remains unknown. The present study generated 3 mutant mouse models with...