pharmacotherapy

In 1960s Britain a chasm of opposing agendas and social distance opened up between doctors treating drug addiction and their patients. This cell of the Drug Treatment Matrix examines how bridging such chasms makes treatment more effective...

Effectiveness Bank Analysis: Keep Maintaining Opiate-Dependent Prisoners From the USA, a rare randomised trial found in favour of continuing methadone maintenance when patients entered prison rather than compulsory withdrawal. The potential...

Trials challenge the need for the widely accepted policy of making opioid-dependent patients take their methadone or other opioid substitutes at the clinic or pharmacy, but ‘no difference’ findings may be due to the limitations of the...

Abstract Study Objectives There remains an important and unmet need for fully effective and acceptable treatments in obstructive sleep apnea (OSA). At present, there are no approved drug treatments. Dronabinol has shown promise for OSA...

In 2013 nalmefene was authorised for moderating drinking among patients not in need of detoxification, extending pharmacotherapy to less dependent drinkers. Though uniquely authorised for this purpose, this review found other (and probably...

Abstract Randomized clinical trials have established the efficacy of naltrexone for reducing quantity of alcohol consumption and incidence of relapse to heavy drinking. To evaluate putative treatment mechanisms, human laboratory studies...

Conducted in 1962 and 1963 in Atlanta in the USA, the featured article seems the first to have tested whether problem-drinking offenders will take a drug which enforces abstinence by generating deterrent reactions to alcohol, if the...