Abstract

Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use disorder (SUD). Variants in the ADGRL3 (LPHN3) gene predispose to ADHD and predict ADHD severity, disruptive behaviors comorbidity, long-term outcome, and response to treatment. In this study, we investigated whether variants within ADGRL3 are associated with SUD, a disorder that is frequently co-morbid with ADHD. Using family-based, case-control, and longitudinal...

Gene-environment interactions occur when different surroundings make it more or less likely for a particular trait or disorder to develop.

The concept of ‘alcogenic’ environments describes features, such as alcohol outlet density or marketing, which influence patterns of alcohol consumption.

A recent study, which analysed longitudinal data of 18–26-year-olds, has examined the link between genetic variation in alcohol problems and the number of alcohol outlets in a community.

The results from the study found that:

• There was evidence to suggest that the extent of genetic and...

Abstract

Rationale

Alcoholism is a primary, chronic relapsing disease of brain reward, motivation, memory, and related circuitry. It is characterized by an individual’s continued drinking despite negative consequences related to alcohol use, which is exemplified by alcohol use leading to clinically significant impairment or distress. Chronic alcohol consumption increases the expression of innate immune signaling molecules (ISMs) in the brain that alter cognitive processes and promote alcohol drinking.

Objectives

Unraveling the mechanisms of alcohol-induced neuroimmune gene...