A Microglia Sublineage Protects from Sex-Linked Anxiety Symptoms and Obsessive Compulsion

Source:

Tränkner, D., Boulet, A., Peden, E., Focht, R., Van Deren, D., & Capecchi, M. (2019). A microglia sublineage protects from sex-linked anxiety symptoms and obsessive compulsion. Cell reports, 29(4), 791-799.

Highlights

•A microglia sublineage derived from Hoxb8-expressing precursors serves unique functions

•Dysfunction of Hoxb8-lineage microglia causes anxiety symptoms and obsessive compulsion

•Female sex hormones worsen the pathology caused by Hoxb8-lineage microglia dysfunction