Changes in Cigarette Consumption With Reduced Nicotine Content Cigarettes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage 3 Randomized Clinical Trials

Source:

Higgins ST, Tidey JW, Sigmon SC, et al. Changes in Cigarette Consumption With Reduced Nicotine Content Cigarettes Among Smokers With Psychiatric Conditions or Socioeconomic Disadvantage: 3 Randomized Clinical Trials. JAMA Netw Open. 2020;3(10):e2019311. doi:10.1001/jamanetworkopen.2020.19311

Key Points

Question  Does reducing the nicotine content of cigarettes decrease smoking rates and nicotine dependence severity among adults with psychiatric disorders or socioeconomic disadvantage?

Findings  These 3 randomized clinical trials including 775 participants with affective disorders, opioid use disorder, or socioeconomic disadvantage found that reducing nicotine content significantly decreased total cigarettes smoked daily and nicotine dependence severity.

Meaning  These results further demonstrate that reducing nicotine content of cigarettes to low levels has potential to benefit populations at high risk for tobacco use, addiction, and smoking-attributable morbidity and mortality.