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Cocaine Elicits Autophagic Cytotoxicity via a Nitric Oxide-GAPDH Signaling Cascade

Scientific article

19 January 2016

Abstract Cocaine exerts its behavioral stimulant effects by facilitating synaptic actions of neurotransmitters such as dopamine and serotonin. It is also neurotoxic and broadly cytotoxic, leading to overdose deaths. We demonstrate that the...

New Evidence in Mice That Cocaine Makes Brain Cells Cannibalize Themselves

News

Working with mice, researchers at Johns Hopkins have contributed significant new evidence to support the idea that high doses of cocaine kill brain cells by triggering overactive autophagy, a process in which cells literally digest their...

Source: https://twitter.com/HopkinsMedicine/status/855446793730916357

5th International Conference on Novel Psychoactive Substances (NPS)

23 October 2017

Vienna

Austria

The 5th International Conference on Novel Psychoactive Substances will be held from 23 to 24 October 2017 at the United Nations in Vienna, Austria. The conference is jointly organised by the United Nations Office on Drugs and Crime (UNODC), the European Monitoring Centre for Drugs and Drug

ISSUP Mexico 2017

News

At the beginning of April ISSUP’s Deputy Executive Director, Joanna Travis-Roberts, headed to Cancún, Mexico to plan for this year’s Annual ISSUP Workshop.

EMCDDA Treatment Standards and Best Practice

News

Discover what works (and what doesn't work) in the areas of drug prevention, treatment and social reintegration.

Effectiveness Bank Matrix Bite: Psychosocial Therapies in the Treatment System

Book

19 April 2017

This is one of 25 cells in the Alcohol Treatment Matrix. The cell discusses key research relating to the roles of psychosocial therapies in local treatment systems. In particular, their role in creating a cost-effective mix of services...

Should Opioid Dependent Patients Receive Immediate Access to Medical Treatment?

Scientific article

18 April 2017

New research supported by the National Institute on Drug Abuse (NIDA) has found through a comparison of treatment approaches for opioid dependence that, in an emergency setting, combining the medication buprenorphine with on-going care is...

Can Abstaining from Alcohol Help to Fight the Spread of HIV?

News

Studies have shown that alcohol may play a role in more that 13% of deaths resulting from infectious diseases, including HIV. Evidence suggests that alcohol consumption negatively affects the fight against HIV primarily by: Increasing the...

Could LSD Have a Role in New Therapeutic Treatments?

Scientific article

10 April 2017

New research published in the journal Translational Psychiatry has found that LSD reduces activity in the region of the brain responsible for negative emotions such as fear. The researchers call this the drug’s ‘de-frightening effect’ and...

Does Smoking Cigarettes Increase the Chance of Relapse into Illegal Substance Use?

Scientific article

5 April 2017

Among people recovering from substance use disorders, those who smoke are more likely to relapse three years later compared to those who do not, according to new findings published in The Journal of Clinical Psychiatry. Treatment for...